Recording the adult zebrafish cerebral field potential during pentylenetetrazole seizures
نویسندگان
چکیده
منابع مشابه
Seizures Induced by Pentylenetetrazole in the Adult Zebrafish: A Detailed Behavioral Characterization
Pentylenetetrazole (PTZ) is a common convulsant agent used in animal models to investigate the mechanisms of seizures. Although adult zebrafish have been recently used to study epileptic seizures, a thorough characterization of the PTZ-induced seizures in this animal model is missing. The goal of this study was to perform a detailed temporal behavior profile characterization of PTZ-induced seiz...
متن کاملClosed-loop neural stimulation for pentylenetetrazole-induced seizures in zebrafish
Neural stimulation can reduce the frequency of seizures in persons with epilepsy, but rates of seizure-free outcome are low. Vagus nerve stimulation prevents seizures by continuously activating noradrenergic projections from the brainstem to the cortex. Cortical norepinephrine then increases GABAergic transmission and increases seizure threshold. Another approach, responsive nervous stimulation...
متن کاملValerenic acid and Valeriana officinalis extracts delay onset of Pentylenetetrazole (PTZ)-Induced seizures in adult Danio rerio (Zebrafish)
BACKGROUND Anticonvulsant properties have been attributed to extracts of the herbal medicine Valeriana officinalis. Our aims were to examine the anticonvulsant properties of valerenic acid and valerian extracts and to determine whether valerian preparations interact with the activity of other anti-epileptic drugs (phenytoin or clonazepam). To achieve these goals, we validated the adult zebrafis...
متن کاملCerebral blood flow velocity during neonatal seizures.
AIM To determine if cerebral blood flow velocity increases during all types of neonatal seizure, and whether the effect is due solely to an increase in blood pressure, transmitted to the cerebral circulation when autoregulation is impaired. METHODS Seizures were diagnosed in 11 high risk neonates using cotside 16 channel video-EEG polygraphy. EEG, cerebral blood flow velocity (CBFV) using tra...
متن کاملHyperthermic seizures and hyperthermia in immature rats modify the subsequent pentylenetetrazole-induced seizures
It has been described that febrile seizures during infancy increase risk of subsequent non-febrile seizures during the adulthood. However, latency period between febrile seizure and the onset of the first spontaneous seizure has not been evaluated. The present study was designed to investigate the susceptibility to subsequent seizures in immature rats that had experienced early-life hyperthermi...
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ژورنال
عنوان ژورنال: Journal of Neuroscience Methods
سال: 2011
ISSN: 0165-0270
DOI: 10.1016/j.jneumeth.2011.06.001